The anaphase-promoting complex/cyclosome: APC/C.
نویسندگان
چکیده
The major ubiquitin ligase required for mitosis is the anaphase-promoting complex/cyclosome (APC/C). This unusually complex E3 ubiquitin ligase targets cell-cycle-related proteins such as cyclins and securin for degradation by the proteasome in mitosis and meiosis. The APC/C is regulated by phosphorylation, as well as by various activators and inhibitors that alter its substrate specificity at different phases of the cell cycle. Such tight control ensures appropriately timed degradation of key cell-cycle regulators.
منابع مشابه
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its coactivator Cdc20 (APC/C(Cdc20)). Before chromosome biorientation, anaphase is delayed by a mitotic checkpoint complex (MCC) that inhibits APC/C(Cdc20). We used single-particle electron microscopy to obta...
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عنوان ژورنال:
- Journal of cell science
دوره 119 Pt 12 شماره
صفحات -
تاریخ انتشار 2006